Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Kedar V, McDonough H, Arya R, Li HH, Rockman HA, Patterson C. Curr Opin Clin Nutr Metab Care 4: 183-190, 2001 What do we really know about the ubiquitin-proteasome pathway in muscle atrophy. Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle. Hilder TL, Tou JC, Grindeland RE, Wade CE, Graves LM. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL. Skeletal muscle hypertrophy and atrophy signaling pathways. RING for destruction? Curr Biol 10: R84-R87, 2000 Mammalian MAP kinase signalling cascades. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. Cell 119: 285-298, 2004Ĭentner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S. IKK $\beta$ /NF- $\kappa$ B activation causes severe muscle wasting in mice. Physiol Rev 71: 541-585, 1991Ĭai D, Frantz JD, Jr Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models. Production of rat muscle atrophy by cast fixation. Identification of ubiquitin ligases required for skeletal muscle atrophy. J Neuroimmunol 170: 41-48, 2005īodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ. MuSK antibody positive myasthenia gravis plasma modifies MuRF-1 expression in C2C12 cultures and mouse muscle in vivo. From these results, we suggest that the expression of MuRF1 in cast-immobilized atrophy is regulated by p38 MAPK in rat gastrocnemius muscles.īenveniste O, Jacobson L, Farrugia ME, Clover L, Vincent A. Changes in the sizes of L6 myoblasts in response to starvation were also reversed by their transfection with MuRF1 small interfering RNA or treatment with SB203580. The expression of MuRF1 was also elevated in serum-starved L6 myoblasts, but was significantly attenuated by SB203580, an inhibitor of p38 MAPK. The starvation of L6 rat skeletal myoblasts under serum-free conditions induced the phosphorylation of p38 MAPK and the characteristics typical of cast-immobilized gastrocnemius muscle. Cast immobilization significantly elevated the expression of MuRF1 and the phosphorylation of p38 MAPK. Histological analysis revealed that cast immobilization induced the atrophy of the gastrocnemius muscle, with diminution of muscle weight and cross-sectional area after 14 days. In this study, we investigated the involvement of mitogen-activated protein kinase (MAPK) in the expression of muscle-specific RING finger 1 (MuRF1) during atrophy of the rat gastrocnemius muscle. However, the cellular mechanisms of the atrophic process are poorly understood. Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors.
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